Sharon, lets make sure we have a couple of things verified,
The pump is running, and circulating the water in the basement loop when the zone valve is manually open.
If you manually open the 1st floor zone valve, with the basement valve closed, you are not getting heat on the 1st floor?? Touch the baseboard pipes and see if they are warm/hot.
What is the water temp in the boiler at this time??
Is the water hot on both sides of the 1st floor zone valve?? I don't think an air bubble in the 1st floor loop could air lock your pipes. Is there any chance the pipes are frozen and blocked by ice?? I hope not.
Locate the pipe going out to the baseboard loop and the one coming back. use your hand to see if they are both cold, or only warm. Then find on the 1st floor, the last baseboard unit, before the water returns to the basement and the boiler. Inside the metal cover at the elbow there should be either a small can like a small bottle of aspirin, or a valve about the size of the tip of a finger. If it is the can type there will be a cap on top like a tire-valve cap. make sure this cap is not tight, it should be loose to let the air out. If it is the smaller type, there will be a screw in the center of the top of the valve, use a good fitting screwdriver to loosen the screw a half turn or so, air will come out if there is any, or water if no air.
If there is no bleed valve or canister, find the guy who plumbed the place and kick him in the shins. I think it's code that there is a bleed valve on the end of the horozontal run prior to the down return to the boiler.
Something is either closed off, or not opening, or frozen up or ?? If you have the basement warm the floor above will be warm too, so the 1st floor pipes should not be frozen.