I've been running 50:1 or leaner in every 2-stroke I've owned in the past 20 years. Never had to rebuild one twice, if that tells you anything. No marketing hype here.
My dirt machines all used to get one bottle of Golden Spectro to 5 gallons of gas. One bottle = 12.3 oz. .. which comes out to 52:1. Ran that in my '87 Honda TRX250R for over 2 very hard years without even changing the spark plug. The day I sold it, it still started first kick & pulled the front wheels skyward in all 6 gears.
I always mixed in 5 gallon batches, because I would go through 5 gallons in one weekend - that's how much riding I did back then. I can't even tell you how many 5 gallon cans I burned in that machine in 2 years - over 50 at least ( can't ride in 2' of snow with a rear wheel drive race quad ). Mostly full throttle, climbing the steepest sand hills in the pit, & a little trail riding mixed in.
The thing with premix is, the more oil you use, the LEANER it makes your fuel/air mixture. So you can actually seize an engine using TOO MUCH oil. Lots of people don't understand this. Lean fuel/air mixes run hotter & are more prone to detonation or pre-ignition - both deadly to 2-strokes no matter how much or what type of oil you use. With this knowledge you will never seize a 2-stroke with any oil/gas ratio. Oil displaces fuel.
So if you change to a richer oil/fuel mix, you need to add more fuel to correct. Turn those screws OUT. The opposite is true for leaner mixes. I find that my 2-strokes make the most power on the leanest possible oil/fuel mix.
I run Amsoil Dominator in my RD350 exclusively since I restored it. Do you think I would run that if synthetics weren't what they've been advertised to be? I don't have the dough to rebuild that thing, so I use the best there is. Lots of guys tear down their engines every year for re-ringing. I run mine for years & never touch the insides again in most cases. But I also can tell just by listening to one run if it needs to be richer or leaner.
Hard starting when hot = too rich on the low speed circuit - turn the screw in a bit ... but not so far that it goes BOOOOOOOG when you hit the throttle. If you need the choke to start it when it;s hot, then it's too lean. Turn the screw out ... but not so much that it starts to break up, or sound like a 4-stroke. You want that smooth, even buzzzzzzz. And also remember - the low speed circuit has nothing to do with wide open throttle, & vice versa. Actually the low speed circuit adds a small amount of fuel to wide open throttle because all circuits overlap, but it's insignificant, & can be compensated for by adjusting the high speed circuit last.