Alternate Route 2: From Endicott, New York and I-86/(Rt. 17) head South on Rt. 26 , this will turn into Rt. 267 once you cross the border. Contiune south on Rt. 267 to Meshoppen and Rt. 6. This is probably the most direct and fastest way but not by a whole lot, the upper part of it is very counrtry road and the speed limit is 45, the lower part below Lawton is 55mph.
Just a note. I live on the upper half of this road and although the upper half is 45 mph speed limit. Expect to get run over if you don't keep it above 55-70.