Microsoft recently releaased a cross-browser and more importantly cross platform plug-in called silverlight. This will allow support for playback of WMV files on many different browsers or the Mac platform, least that's what the documentation says. It's similar to flash except much more ability, more importantly at least IMO is the WMV suport. Windows users will be able to create their masterpiece in Windows Movie Maker or other editor encode to WMV and upload directly to here without any further intervention by me having to reencode it to make it friendly for the Mac community or those not using IE.
Currently it only supports WMV, WMA and MP3 so Mac users are still slightly out in the cold but Ihopefully other formats like MOV or Divx will be supported in the future.
I want to use this for embedding video and audio content here, the only other realistic option is flash and chances are no one is going to have flash encoder.
Anyhow I have test page up, this will require that you install the plug-in from microsoft if you don't alredy have it. Chances are this is going to become popular so you're going to run into it sooner later.
What I would really like is feedback from the Mac users if it works or not.
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Note that the file I used here is 500kbps so you'll need cable or fast DSL connection.
More info here: http://silverlight.net/